Article
T-cell subset analysis of Lewis lung carcinoma tumor rejection: heterogeneity of effectors and evidence for negative regulatory lymphocytes correlating with metastasis.
Cancer research - 1 Dec 1992
Gelber C, Eisenbach L, Feldman M, Goodenow R S
Abstract excerpt
We have analyzed the phenotypes of the T-cell subsets generated in response to Lewis lung carcinoma clones in C57BL/6J recipients. The metastatic derivative, which expresses low levels of H-2Kb gene, predominantly elicited CD8, V beta 8, and V beta 9+ T-cells. The nonmetastatic clone expressing high levels of H-Kb gene triggered a more heterogeneous response of V beta-5, -6, -8, -9, and -11 CD8+ T-cells....
Topics
- Animals
- Antigenic Modulation
- CD4-CD8 Ratio
- CD8 Antigens
- Carcinoma
- Cell Separation
- Cytotoxicity, Immunologic
- Flow Cytometry
- Immunity, Cellular
- Immunocompromised Host
- Lung Neoplasms