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Article

Activation and expansion of cytotoxic T lymphocytes from tumor-draining lymph nodes.

Cancer immunology, immunotherapy : CII - 1 Jan 1990

McKinnon J G, Hoover S K, Inge T H, Bear H D

Abstract excerpt

Large numbers of cytotoxic T lymphocytes (CTL) could be generated from tumor-draining lymph nodes (DLN) from mice bearing PHS-5 tumor by culturing at low density with autologous tumor cell stimulators and 20 U/ml recombinant interleukin-2 (IL-2). Outgrowth of metastatic tumor cells in culture was prevented by use of this hypoxanthine/aminopterin/thymidine-sensitive mutant of P815, PHS-5. After 9 days in culture,...

Topics

Animals
Cells, Cultured
Cytotoxicity, Immunologic
Female
Immunotherapy, Adoptive
Liver Neoplasms
Lymph Nodes
Lymphocyte Activation
Mast-Cell Sarcoma
Mice
Mice, Inbred Strains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Staging

Phenotype

Spleen

T-Lymphocytes, Cytotoxic

Time Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 2126983
DOI: 10.1007/BF01741722
PMCID: PMC11038535

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2126983-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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