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Article

Activation and expansion of cytotoxic T lymphocytes from tumor-draining lymph nodes.

Cancer immunology, immunotherapy : CII - 1 Jan 1990

McKinnon J G, Hoover S K, Inge T H, Bear H D

Abstract excerpt

Large numbers of cytotoxic T lymphocytes (CTL) could be generated from tumor-draining lymph nodes (DLN) from mice bearing PHS-5 tumor by culturing at low density with autologous tumor cell stimulators and 20 U/ml recombinant interleukin-2 (IL-2). Outgrowth of metastatic tumor cells in culture was prevented by use of this hypoxanthine/aminopterin/thymidine-sensitive mutant of P815, PHS-5. After 9 days in culture,...

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Identifiers

PMID: 2126983
DOI: 10.1007/BF01741722
PMCID: PMC11038535

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Source receipt: pubmed, retrieved 7 Sept 2026.

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