Article
Therapeutic use of a long-term cytotoxic T cell line recognizing a common tumour-associated antigen: the pattern of in vitro reactivity predicts the in vivo effect on different tumours.
Cancer immunology, immunotherapy : CII - 1 Jan 1991
Rodolfo M, Bassi C, Salvi C, Parmiani G
Abstract excerpt
A long-term-cultured cytotoxic T lymphocyte (CTL) line (E/88) was obtained from splenic lymphocytes of BALB/c (H-2d) mice bearing the weakly immunogenic colonic carcinoma C26. This line was shown to be alpha/beta TCR + V beta 6 + CD3 + CD8 + CD4- and to recognize a common tumour-associated antigen on syngeneic carcinomas and sarcomas in a major-histocompatibility--complex-restricted and...
Topics
- Animals
- Antibodies, Monoclonal
- Antigens, Neoplasm
- Cell Line
- Cytotoxicity, Immunologic
- Immunotherapy, Adoptive
- Interleukin-2
- Mice
- Mice, Inbred Strains
- Neoplasms, Experimental