Evidence that wild-type TP53, and not genes on either chromosome 1 or 11, controls the tumorigenic phenotype of the human fibrosarcoma HT1080.

doi:10.1002/gcc.2870090407

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Article

Evidence that wild-type TP53, and not genes on either chromosome 1 or 11, controls the tumorigenic phenotype of the human fibrosarcoma HT1080.

Genes, chromosomes & cancer - 1 Apr 1994

Anderson M J, Casey G, Fasching C L, Stanbridge E J

Abstract excerpt

The specific transfer of normal chromosomes via microcell fusion has been instrumental in identifying putative tumor suppressor gene loci in a variety of human cancers. Using this same technique it has been proposed that the tumorigenicity of the human fibrosarcoma cell line HT1080 is controlled...

Topics

Animals
Chromosomes, Human, Pair 1
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 17
DNA, Complementary
DNA, Neoplasm
Fibrosarcoma
Genes, p53
Humans
Hybrid Cells
Karyotyping
Mice
Mice, Nude
Neoplasm Transplantation
Phenotype
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Transfection

Source

Open in PubMed

Identifiers

PMID: 7519049
DOI: 10.1002/gcc.2870090407

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7519049-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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