Article
Susceptibility for N-ras-mediated transformation requires loss of tumor suppressor activity.
Somatic cell and molecular genetics - 1 Jan 1990
Krizman D B, Giovanella B C, Tainsky M A
Abstract excerpt
We have been using PA-1 human teratocarcinoma cells to study mechanisms by which oncogenes induce transformation. Tumorigenic PA-1 cells at passages greater than 100 (greater than P100) contain a spontaneously activated N-ras oncogene, while earlier-passage preneoplastic cells contain only the ge...
Topics
- Blotting, Southern
- Cell Transformation, Neoplastic
- Child
- Chromosome Deletion
- Chromosomes, Human, Pair 1
- Chromosomes, Human, Pair 11
- Chromosomes, Human, Pair 4
- Clone Cells
- Female
- Genes, ras
- Humans
- Hybrid Cells
- Karyotyping
- Phenotype
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins p21(ras)
- Suppression, Genetic