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Article

Susceptibility for N-ras-mediated transformation requires loss of tumor suppressor activity.

Somatic cell and molecular genetics - 1 Jan 1990

Krizman D B, Giovanella B C, Tainsky M A

Abstract excerpt

We have been using PA-1 human teratocarcinoma cells to study mechanisms by which oncogenes induce transformation. Tumorigenic PA-1 cells at passages greater than 100 (greater than P100) contain a spontaneously activated N-ras oncogene, while earlier-passage preneoplastic cells contain only the germ-line protooncogene and are nontumorigenic. One preneoplastic cell clone of PA-1 cells can be transformed by...

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Identifiers

PMID: 2408157
DOI: 10.1007/BF01650476

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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