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Article

Inserting chromosome 18 into pancreatic cancer cells switches them to a dormant metastatic phenotype.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Oct 2003

Lefter Liviu P, Sunamura Makoto, Furukawa Toru, Takeda Kazunori, Kotobuki Noriko, Oshimura Mitsuo, Matsuno Seiki, Horii Akira

Abstract excerpt

We demonstrated previously that restoration of chromosome 18 suppressed growth of pancreatic cancer cells in vitro, as well as that of tumors inoculated into nude mice. We also demonstrated that loss of 18q was associated with poor prognosis. Hence there is the possibility that the 18q arm harbors a gene(s) implicated in tumor progression and/or metastasis. In this study, we evaluated the effect of restoring...

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PMID: 14581380

Genes

SMAD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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