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Article

17p allelic losses in diploid cells of patients with Barrett's esophagus who develop aneuploidy.

Cancer research - 1 May 1994

Blount P L, Galipeau P C, Sanchez C A, Neshat K, Levine D S, Yin J, Suzuki H, Abraham J M, Meltzer S J, Reid B J

Abstract excerpt

Inactivation of the p53 gene, located on chromosome 17p, leads to genetic instability and aneuploidy in vitro. Aneuploid cell populations from Barrett's adenocarcinomas have a high prevalence of 17p allelic losses, and there is substantial evidence that the target of these losses is the p53 gene. If 17p allelic losses lead to aneuploidy in Barrett's esophagus, then they should be present in diploid cells from...

Topics

Adenocarcinoma
Alleles
Aneuploidy
Barrett Esophagus
Base Sequence
Chromosome Deletion
Chromosomes, Human, Pair 17
DNA Mutational Analysis
Esophageal Neoplasms
Genes, p53
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ki-67 Antigen

Molecular Sequence Data

Neoplasm Proteins

Nuclear Proteins

Sequence Analysis, DNA

Source

Identifiers

PMID: 8162566

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8162566-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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