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Article

Clonal ordering of 17p and 5q allelic losses in Barrett dysplasia and adenocarcinoma.

Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 1993

Blount P L, Meltzer S J, Yin J, Huang Y, Krasna M J, Reid B J

Abstract excerpt

Both 17p and 5q allelic losses appear to be involved in the pathogenesis or progression of many human solid tumors. In colon carcinogenesis, there is strong evidence that the targets of the 17p and 5q allelic losses are TP53, the gene encoding p53, and APC, respectively. It is widely accepted that 5q allelic losses precede 17p allelic losses in the progression to colonic carcinoma. The data, however, supporting...

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Share to Adenocarcinoma
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Share to Chromosomes, Human, Pair 17

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 8475062
DOI: 10.1073/pnas.90.8.3221
PMCID: PMC46271

Genes

APC

Provenance

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Source receipt: pubmed, retrieved 7 Sept 2026.

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