Article
Clonal ordering of 17p and 5q allelic losses in Barrett dysplasia and adenocarcinoma.
Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 1993
Blount P L, Meltzer S J, Yin J, Huang Y, Krasna M J, Reid B J
Abstract excerpt
Both 17p and 5q allelic losses appear to be involved in the pathogenesis or progression of many human solid tumors. In colon carcinogenesis, there is strong evidence that the targets of the 17p and 5q allelic losses are TP53, the gene encoding p53, and APC, respectively. It is widely accepted tha...
Topics
- Adenocarcinoma
- Alleles
- Aneuploidy
- Barrett Esophagus
- Chromosomes, Human, Pair 17
- Chromosomes, Human, Pair 5
- Colonic Neoplasms
- Esophagus
- Flow Cytometry
- Genes, APC
- Genes, p53
- Humans
- Polymerase Chain Reaction
- Precancerous Conditions