Article
Sporadic and familial pheochromocytomas are associated with loss of at least two discrete intervals on chromosome 1p.
Cancer research - 15 Dec 2000
Benn D E, Dwight T, Richardson A L, Delbridge L, Bambach C P, Stowasser M, Gordon R D, Marsh D J, Robinson B G
Abstract excerpt
Pheochromocytomas are tumors of the adrenal medulla originating in the chromaffin cells derived from the neural crest. Ten % of these tumors are associated with the familial cancer syndromes multiple endocrine neoplasia type 2, von Hippel-Lindau disease (VHL), and rarely, neurofibromatosis type 1, in which germ-line mutations have been identified in RET, VHL, and NF1, respectively. In both the sporadic and...
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