Article
Molecular karyotype of sporadic unilateral retinoblastoma tumors.
Retina (Philadelphia, Pa.) - 1 Jan 2000
Ganguly Arupa, Nichols Kim E, Grant Gregory, Rappaport Eric, Shields Carol
Abstract excerpt
BACKGROUND: Retinoblastoma (RB) is a childhood ocular malignancy associated with mutations in RB1, a tumor susceptibility gene. Inactivation of both copies of the RB1 gene in a retinal cell is followed by the sequential acquisition of additional genetic changes that define the course to tumor formation. METHODS: To identify the genetic events that cooperate with loss of the RB1 gene function, we performed a whole...
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