Article
Different patterns of allelic loss (loss of heterozygosity) in recurrent human pituitary tumors provide evidence for multiclonal origins.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Oct 2000
Clayton R N, Pfeifer M, Atkinson A B, Belchetz P, Wass J A, Kyrodimou E, Vanderpump M, Simpson D, Bicknell J, Farrell W E
Abstract excerpt
Sporadic human pituitary tumors are benign adenomas of monoclonal origin. This implies that they arise from de novo somatic mutation(s) within a single pituitary cell. The availability of original and recurrent/regrown tumors from the same patient allowed testing of the prediction that recurrent/regrown tumors have identical genetic abnormalities as the original tumor sample. We used PCR amplification, from...
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