Article
Role of phospholipase C in Dictyostelium: formation of inositol 1,4,5-trisphosphate and normal development in cells lacking phospholipase C activity.
The EMBO journal - 1 Apr 1994
Drayer A L, Van der Kaay J, Mayr G W, Van Haastert P J
Abstract excerpt
The micro-organism Dictyostelium uses extracellular cAMP to induce chemotaxis and cell differentiation. Signals are transduced via surface receptors, which activate G proteins, to effector enzymes. The deduced protein sequence of Dictyostelium discoideum phosphatidylinositol-specific phospholipas...
Topics
- Animals
- Cell Differentiation
- Chemotaxis
- Cyclic AMP
- Dictyostelium
- Dose-Response Relationship, Drug
- Inositol 1,4,5-Trisphosphate
- Inositol Phosphates
- Mutation
- Second Messenger Systems
- Signal Transduction