Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns(3,4,5)P3 interactions.

Cell - 5 Sept 2003

Luo Hongbo R, Huang Yi Elaine, Chen Jianmeng C, Saiardi Adolfo, Iijima Miho, Ye Keqiang, Huang Yunfei, Nagata Eiichiro, Devreotes Peter, Snyder Solomon H

Abstract excerpt

Inositol phosphates are well-known signaling molecules, whereas the inositol pyrophosphates, such as diphosphoinositol pentakisphosphate (InsP7/IP7) and bis-diphosphoinositol tetrakisphosphate (InsP8/IP8), are less well characterized. We demonstrate physiologic regulation of Dictyostelium chemotaxis by InsP7 mediated by its competition with PtdIns(3,4,5)P3 for binding pleckstrin homology (PH) domain-containing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chemotaxis
Share to Chromatography, High Pressure Liquid

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cyclic AMP

Share to Dictyostelium

Share to Guanosine 5'-O-(3-Thiotriphosphate)

Share to Inositol Phosphates

Share to Luminescent Proteins

Share to Phosphatidylinositol Phosphates

Source

Identifiers

PMID: 13678580
DOI: 10.1016/s0092-8674(03)00640-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns(3,4,5)P3 interactions.PMID 13678580Read ↗

A novel Ras-interacting protein required for chemotaxis and cyclic adenosine monophosphate signal relay in Dictyostelium.Semantic proximity Read ↗

Tumor suppressor PTEN mediates sensing of chemoattractant gradients.Semantic proximity Read ↗

Role of phospholipase C in Dictyostelium: formation of inositol 1,4,5-trisphosphate and normal development in cells lacking phospholipase C activity.Semantic proximity Read ↗

TOR complex 2 integrates cell movement during chemotaxis and signal relay in Dictyostelium.Semantic proximity Read ↗

Dictyostelium stress-activated protein kinase alpha, a novel stress-activated mitogen-activated protein kinase kinase kinase-like kinase, is important for the proper regulation of the cytoskeleton.Semantic proximity Read ↗

Essential role of PI3-kinase and phospholipase A2 in Dictyostelium discoideum chemotaxis.Semantic proximity Read ↗

PIP₃-dependent macropinocytosis is incompatible with chemotaxis.Semantic proximity Read ↗

An unconventional myosin required for cell polarization and chemotaxis.Semantic proximity Read ↗

Chemoattractant stimulation of TORC2 is regulated by receptor/G protein-targeted inhibitory mechanisms that function upstream and independently of an essential GEF/Ras activation pathway in Dictyostelium.Semantic proximity Read ↗

Chemotaxis in the absence of PIP3 gradients.Semantic proximity Read ↗

Inositol pyrophosphates as mammalian cell signals.Semantic proximity Read ↗

Molecular genetics of signal transduction in Dictyostelium.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.