Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phospholipase C in Dictyostelium discoideum. Identification of stimulatory and inhibitory surface receptors and G-proteins.

The Biochemical journal - 1 Jan 1994

Bominaar A A, Van Haastert P J

Abstract excerpt

A combined biochemical and genetic approach was used to show that phospholipase C in the cellular slime mould Dictyostelium is under dual regulation by the chemoattractant cyclic AMP (cAMP). This dual regulation involves stimulatory and inhibitory surface receptors and G-proteins. In wild-type cells both cAMP and guanosine 5'-[gamma-thio]triphosphate (GTP[S]) stimulated phospholipase C. In contrast, mutant fgd A,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclic AMP
Share to Dictyostelium
Share to Enzyme Activation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to GTP-Binding Proteins

Share to Inositol 1,4,5-Trisphosphate

Share to Mutation

Share to Phosphoric Monoester Hydrolases

Share to Type C Phospholipases

Source

Open in PubMed Open full text

Identifiers

PMID: 8280098
DOI: 10.1042/bj2970189
PMCID: PMC1137809

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phospholipase C in Dictyostelium discoideum. Identification of stimulatory and inhibitory surface receptors and G-proteins.PMID 8280098Read ↗

Abberant chemotaxis and differentiation in Dictyostelium mutant fgdC with a defective regulation of receptor-stimulated phosphoinositidase C.Semantic proximity Read ↗

Role of phospholipase C in Dictyostelium: formation of inositol 1,4,5-trisphosphate and normal development in cells lacking phospholipase C activity.Semantic proximity Read ↗

Non-chemotactic Dictyostelium discoideum mutants with altered cGMP signal transduction.Semantic proximity Read ↗

G-proteins and the inositol cycle in Dictyostelium discoideum.Semantic proximity Read ↗

Essential role of PI3-kinase and phospholipase A2 in Dictyostelium discoideum chemotaxis.Semantic proximity Read ↗

PldB, a putative phospholipase D homologue in Dictyostelium discoideum mediates quorum sensing during development.Semantic proximity Read ↗

Arachidonic acid is a chemoattractant for Dictyostelium discoideum cells.Semantic proximity Read ↗

Chemoattractant stimulation of TORC2 is regulated by receptor/G protein-targeted inhibitory mechanisms that function upstream and independently of an essential GEF/Ras activation pathway in Dictyostelium.Semantic proximity Read ↗

PLA2 and PI3K/PTEN pathways act in parallel to mediate chemotaxis.Semantic proximity Read ↗

Aggregation of Dictyostelium discoideum is dependent on myristoylation and membrane localization of the G protein alpha-subunit, G alpha 2.Semantic proximity Read ↗

Multiple signal transduction pathways regulate discoidin I gene expression in Dictyostelium discoideum.Semantic proximity Read ↗

Molecular genetics of signal transduction in Dictyostelium.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.