Article
Phospholipase C in Dictyostelium discoideum. Identification of stimulatory and inhibitory surface receptors and G-proteins.
The Biochemical journal - 1 Jan 1994
Bominaar A A, Van Haastert P J
Abstract excerpt
A combined biochemical and genetic approach was used to show that phospholipase C in the cellular slime mould Dictyostelium is under dual regulation by the chemoattractant cyclic AMP (cAMP). This dual regulation involves stimulatory and inhibitory surface receptors and G-proteins. In wild-type ce...
Topics
- Animals
- Cyclic AMP
- Dictyostelium
- Enzyme Activation
- GTP-Binding Proteins
- Guanosine 5'-O-(3-Thiotriphosphate)
- Inositol 1,4,5-Trisphosphate
- Inositol Polyphosphate 5-Phosphatases
- Mutation
- Phosphoric Monoester Hydrolases
- Receptors, Cyclic AMP
- Type C Phospholipases