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Article

Essential role of PI3-kinase and phospholipase A2 in Dictyostelium discoideum chemotaxis.

The Journal of cell biology - 4 Jun 2007

van Haastert Peter J M, Keizer-Gunnink Ineke, Kortholt Arjan

Abstract excerpt

Chemotaxis toward different cyclic adenosine monophosphate (cAMP) concentrations was tested in Dictyostelium discoideum cell lines with deletion of specific genes together with drugs to inhibit one or all combinations of the second-messenger systems PI3-kinase, phospholipase C (PLC), phospholipase A2 (PLA2), and cytosolic Ca(2+). The results show that inhibition of either PI3-kinase or PLA2 inhibits chemotaxis in...

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Source

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Identifiers

PMID: 17535967
DOI: 10.1083/jcb.200701134
PMCID: PMC2064281

Genes

PIP
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Essential role of PI3-kinase and phospholipase A2 in Dictyostelium discoideum chemotaxis.PMID 17535967Read ↗

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