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Article

PLA2 and PI3K/PTEN pathways act in parallel to mediate chemotaxis.

Developmental cell - 1 Apr 2007

Chen Lingfeng, Iijima Miho, Tang Ming, Landree Mark A, Huang Yi Elaine, Xiong Yuan, Iglesias Pablo A, Devreotes Peter N

Abstract excerpt

Directed cell migration involves signaling events that lead to local accumulation of PI(3,4,5)P(3), but additional pathways act in parallel. A genetic screen in Dictyostelium discoideum to identify redundant pathways revealed a gene with homology to patatin-like phospholipase A(2). Loss of this gene did not alter PI(3,4,5)P(3) regulation, but chemotaxis became sensitive to reductions in PI3K activity. Likewise,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17419997
DOI: 10.1016/j.devcel.2007.03.005
PMCID: PMC1986835

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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