Article
Genetic evidence in melanoma and bladder cancers that p16 and p53 function in separate pathways of tumor suppression.
The American journal of pathology - 1 May 1995
Gruis N A, Weaver-Feldhaus J, Liu Q, Frye C, Eeles R, Orlow I, Lacombe L, Ponce-Castaneda V, Lianes P, Latres E
Abstract excerpt
The 9p21 region of human chromosome 9 is a hot spot for chromosomal aberrations in both cultured cell lines and primary tumors. This region contains a gene, P16 (also called MTS1, CDKN2 and p16INK4), that encodes a presumptive negative cell cycle regulator called p16. P16 is deleted or mutated at high frequency in a variety of tumor cell lines including melanoma and bladder carcinoma lines. As such, it is likely...
Topics
- Amino Acid Sequence
- Base Sequence
- Carcinoma, Transitional Cell
- Carrier Proteins
- Cyclin-Dependent Kinase Inhibitor p16
- DNA, Neoplasm
- Genes, Tumor Suppressor
- Genes, p53
- Humans
- Melanoma