Article
[Discovery of a new gene frequently inactivated in human cancers: protein p16, a cell cycle regulator].
Bulletin du cancer - 1 Oct 1994
Bressac-de Paillerets B
Abstract excerpt
Comprehension of cell cycle regulation mechanisms progressed very quickly the past few years. The last discovery concern a known gene, MTS1 (Multiple Tumor suppressor), encoding a protein of M(r) 16K, intrinsic component of the cell cycle machinery. p16 protein inhibits an enzyme called CDK4 (cyclin-dependent kinase 4) which is a kinase implicated in the control of cell proliferation between the G1 and S phases....
Topics
- Carrier Proteins
- Cell Cycle Proteins
- Chromosome Deletion
- Chromosome Mapping
- Cyclin-Dependent Kinase Inhibitor p16
- Genes, Regulator
- Genes, Tumor Suppressor
- Humans
- Mutation