Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

On the transcriptional regulation of methicillin resistance: MecI repressor in complex with its operator.

The Journal of biological chemistry - 23 Apr 2004

García-Castellanos Raquel, Mallorquí-Fernández Goretti, Marrero Aniebrys, Potempa Jan, Coll Miquel, Gomis-Rüth F Xavier

Abstract excerpt

Bacterial resistance to antibiotics poses a serious worldwide public health problem due to the high morbidity and mortality caused by infectious diseases. Most hospital-onset infections are associated with methicillin-resistant Staphylococcus aureus (MRSA) strains that have acquired multiple drug resistance to beta-lactam antibiotics. In a response to antimicrobial stress, nearly all clinical MRSA isolates...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hexosyltransferases
Share to Methicillin

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Methicillin Resistance

Share to Models, Chemical

Share to Muramoylpentapeptide Carboxypeptidase

Share to Penicillin-Binding Proteins

Share to Peptidyl Transferases

Share to Staphylococcus aureus

Source

Identifiers

PMID: 14960592
DOI: 10.1074/jbc.M313123200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

On the transcriptional regulation of methicillin resistance: MecI repressor in complex with its operator.PMID 14960592Read ↗

Mechanisms of Methicillin Resistance in <i>Staphylococcus aureus</i>Semantic proximity Read ↗

The Anti-Repressor MecR2 Promotes the Proteolysis of the mecA Repressor and Enables Optimal Expression of β-lactam Resistance in MRSASemantic proximity Read ↗

Key Genetic Elements and Regulation Systems in Methicillin-Resistant <i>Staphylococcus Aureus</i>Semantic proximity Read ↗

Methicillin-Resistance in Staphylococcus aureus Is Not Affected by the Overexpression in Trans of the mecA Gene Repressor: A Surprising ObservationSemantic proximity Read ↗

Crystal Structures of the Apo and Penicillin-acylated Forms of the BlaR1 β-Lactam Sensor of Staphylococcus aureusSemantic proximity Read ↗

Impact of methicillin resistance on virulence factor expression in <i>Staphylococcus aureus</i> : Insights from gene expression profilingSemantic proximity Read ↗

Redefining the role of the β-lactamase locus in methicillin-resistant Staphylococcus aureus: β-lactamase regulators disrupt the MecI-mediated strong repression on mecA and optimize the phenotypic expression of resistance in strains with constitutive mecA expression.Semantic proximity Read ↗

Whole-genome analysis of an oxacillin-susceptible CC80 mecA-positive Staphylococcus aureus clinical isolate: insights into the mechanisms of cryptic methicillin resistance.Semantic proximity Read ↗

Interaction of Native and Mutant MecI Repressors with Sequences That Regulate mecA , the Gene Encoding Penicillin Binding Protein 2a in Methicillin-Resistant StaphylococciSemantic proximity Read ↗

Non-canonical <i>Staphylococcus aureus</i> pathogenicity island repressionSemantic proximity Read ↗

Structural basis of broad-spectrum β-lactam resistance in Staphylococcus aureusSemantic proximity Read ↗

Expression of <i>mecA</i> reduces the daptomycin susceptibility of <i>Staphylococcus aureus</i>Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.