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Article

Structural mechanism of inhibition of the Rho transcription termination factor by the antibiotic bicyclomycin.

Structure (London, England : 1993) - 1 Jan 2005

Skordalakes Emmanuel, Brogan Andrew P, Park Boon Saeng, Kohn Harold, Berger James M

Abstract excerpt

Rho is a hexameric RNA/DNA helicase/translocase that terminates transcription of select genes in bacteria. The naturally occurring antibiotic, bicyclomycin (BCM), acts as a noncompetitive inhibitor of ATP turnover to disrupt this process. We have determined three independent X-ray crystal structures of Rho complexed with BCM and two semisynthetic derivatives, 5a-(3-formylphenylsulfanyl)-dihydrobicyclomycin (FPDB)...

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Share to Adenosine Triphosphatases
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Bridged Bicyclo Compounds, Heterocyclic

Share to Crystallography, X-Ray

Share to Molecular Structure

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Share to Spectrum Analysis, Raman

Share to Terminator Regions, Genetic

Source

Identifiers

PMID: 15642265
DOI: 10.1016/j.str.2004.10.013

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Structural mechanism of inhibition of the Rho transcription termination factor by the antibiotic bicyclomycin.PMID 15642265Read ↗

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