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Article

Molecular Binding Mechanism of TtgR Repressor to Antibiotics and Antimicrobials

30 Sept 2015

Abstract excerpt

A disturbing phenomenon in contemporary medicine is the prevalence of multidrug-resistant pathogenic bacteria. Efflux pumps contribute strongly to this antimicrobial drug resistance, which leads to the subsequent failure of clinical treatments. The TtgR protein of Pseudomonas putida is a HTH-type transcriptional repressor that controls expression of the TtgABC efflux pump, which is the main contributor to...

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PMID: 26422008
DOI: 10.1371/journal.pone.0138469

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