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Binding of Tetracyclines to Acinetobacter baumannii TetR Involves Two Arginines as Specificity Determinants

19 Jul 2021

Abstract excerpt

Acinetobacter baumannii is an important nosocomial pathogen that requires thoughtful consideration in the antibiotic prescription strategy due to its multidrug resistant phenotype. Tetracycline antibiotics have recently been re-administered as part of the combination antimicrobial regimens to treat infections caused by A. baumannii . We show that the TetA(G) efflux pump of A. baumannii AYE confers resistance to a...

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PMID: 34349752
DOI: 10.3389/fmicb.2021.711158

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