Article
A novel target cell for c-fos-induced oncogenesis: development of chondrogenic tumours in embryonic stem cell chimeras.
The EMBO journal - 1 Sept 1991
Wang Z Q, Grigoriadis A E, Möhle-Steinlein U, Wagner E F
Abstract excerpt
Embryonic stem (ES) cells were used to investigate the target cell specificity and consequences of c-fos when expressed ectopically during embryonic development. Chimeric mice generated with different ES cell clones selected for high exogenous c-fos expression were not affected during embryonic d...
Topics
- Animals
- Blotting, Northern
- Cartilage
- Cell Line
- Cell Transformation, Neoplastic
- Chimera
- Chondrosarcoma
- Collagen
- DNA-Binding Proteins
- Female
- Genetic Vectors
- Immunohistochemistry
- Mice
- Nucleic Acid Hybridization
- Phenotype
- Pregnancy
- Protein-Tyrosine Kinases
- Proto-Oncogene Proteins