Article
Growth and differentiation of embryonic stem cells that lack an intact c-fos gene.
Proceedings of the National Academy of Sciences of the United States of America - 1 Oct 1992
Field S J, Johnson R S, Mortensen R M, Papaioannou V E, Spiegelman B M, Greenberg M E
Abstract excerpt
The c-fos protooncogene encodes a transcription factor that is thought to play a critical role in proliferation and differentiation as well as in the physiological response of mature cells to their environment. To test directly the role of c-fos in growth and differentiation, we generated mouse embryonic stem cell lines in which both copies of the c-fos gene were specifically disrupted by homologous...
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