Article
Growth and differentiation of embryonic stem cells that lack an intact c-fos gene.
Proceedings of the National Academy of Sciences of the United States of America - 1 Oct 1992
Field S J, Johnson R S, Mortensen R M, Papaioannou V E, Spiegelman B M, Greenberg M E
Abstract excerpt
The c-fos protooncogene encodes a transcription factor that is thought to play a critical role in proliferation and differentiation as well as in the physiological response of mature cells to their environment. To test directly the role of c-fos in growth and differentiation, we generated mouse e...
Topics
- Alleles
- Animals
- Cell Differentiation
- Cell Division
- Cinnamates
- Drug Resistance, Microbial
- Embryo, Mammalian
- Gene Deletion
- Genes, fos
- Genetic Vectors
- Genotype
- Hygromycin B
- Kanamycin Kinase
- Kinetics
- Mice
- Phosphotransferases
- RNA, Messenger
- Stem Cells