Article
Antisense-fos RNA causes partial reversion of the transformed phenotypes induced by the c-Ha-ras oncogene.
Molecular and cellular biology - 1 Apr 1990
Ledwith B J, Manam S, Kraynak A R, Nichols W W, Bradley M O
Abstract excerpt
Several lines of evidence have suggested that c-fos may act downstream from c-Ha-ras in a growth-regulatory signal transduction pathway. We used antisense RNA to inhibit c-fos gene expression and investigated the effects of diminished c-fos expression on the phenotypes induced by the EJ c-Ha-ras...
Topics
- Animals
- Blotting, Southern
- Cell Division
- Cell Line
- Cell Transformation, Neoplastic
- Cells, Cultured
- DNA Replication
- DNA, Neoplasm
- Dexamethasone
- Female
- Gene Expression Regulation, Neoplastic
- Genes, ras
- Humans
- Kinetics
- Mice
- Mice, Nude
- Neoplasm Transplantation
- Phenotype