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Article

Antisense-fos RNA causes partial reversion of the transformed phenotypes induced by the c-Ha-ras oncogene.

Molecular and cellular biology - 1 Apr 1990

Ledwith B J, Manam S, Kraynak A R, Nichols W W, Bradley M O

Abstract excerpt

Several lines of evidence have suggested that c-fos may act downstream from c-Ha-ras in a growth-regulatory signal transduction pathway. We used antisense RNA to inhibit c-fos gene expression and investigated the effects of diminished c-fos expression on the phenotypes induced by the EJ c-Ha-ras oncogene in NIH 3T3 cells. Immunofluorescent staining demonstrated that the antisense RNA caused a marked reduction in...

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Identifiers

PMID: 1690847
DOI: 10.1128/mcb.10.4.1545-1555.1990
PMCID: PMC362259

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