Article
Antagonistic regulation of cell-matrix adhesion by FosB and DeltaFosB/Delta2DeltaFosB encoded by alternatively spliced forms of fosB transcripts.
Molecular biology of the cell - 1 Nov 2008
Ohnishi Yoshinori N, Sakumi Kunihiko, Yamazaki Katsuhisa, Ohnishi Yoko H, Miura Tomofumi, Tominaga Yohei, Nakabeppu Yusaku
Abstract excerpt
Among fos family genes encoding components of activator protein-1 complex, only the fosB gene produces two forms of mature transcripts, namely fosB and DeltafosB mRNAs, by alternative splicing of an exonic intron. The former encodes full-length FosB. The latter encodes DeltaFosB and Delta2DeltaFosB by alternative translation initiation, and both of these lack the C-terminal transactivation domain of FosB. We...
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