Article
Mediation of suppression of c-fos transcription in rasT24-transformed rat cells by a cis-acting repressor element.
Molecular carcinogenesis - 1 Jun 1994
Osei-Frimpong J, Sepulveda J, Rangdaeng S, Lebovitz R M
Abstract excerpt
Prolonged expression of activated ras mutants resulted in both neoplastic transformation and suppression of serum-induced c-fos expression in Rat1 fibroblasts. Expression of other serum-inducible genes, including c-jun and beta-actin, was not suppressed in ras-transformed Rat1 cells, indicating t...
Topics
- Animals
- Base Sequence
- Cell Transformation, Neoplastic
- Cells, Cultured
- Fibroblasts
- Gene Expression Regulation, Neoplastic
- Genes, fos
- Genes, ras
- Molecular Sequence Data
- Mutation
- Promoter Regions, Genetic
- RNA, Messenger
- Rats
- Repressor Proteins
- Transcription, Genetic
- Transformation, Genetic