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Article

A selective transcriptional induction system for mammalian cells based on Gal4-estrogen receptor fusion proteins.

1 Mar 1993

Abstract excerpt

Most mammalian cells neither express any Gal4-like activity nor endogenous estrogen receptor, thus rendering estrogen an inert signal for them. For these two reasons we have developed a selective induction system based on the estrogen-regulable transcription factor Gal-ER. Gal-ER consists of the DNA-binding domain of the yeast Gal4 protein fused to the hormone-binding domain of the human estrogen receptor and...

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PMID: 8446579
DOI: 10.1073/pnas.90.5.1657

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