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Article

Nonrandom allelic variation in the regulatory complex of HLA class I genes.

Human immunology - 1 Sept 1994

Cereb N, Lee S, Maye P, Kong Y, Yang S Y

Abstract excerpt

Recently, we have demonstrated that the HLA class I regulatory complex (CRC) is conserved in a locus-specific manner with limited allelic variation. In this study, we have analyzed the CRC sequences of the alleles that showed variation from a total of 22 well-characterized, HLA-homozygous B-LCLs, using PCR amplification of genomic DNA and direct sequencing. We compared the sequences of these alleles with their...

Topics

Alleles
B-Lymphocytes
Base Sequence
Cell Line
HLA-A Antigens
HLA-B Antigens
HLA-C Antigens
Humans
Molecular Sequence Data
Sequence Homology, Nucleic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 7836064
DOI: 10.1016/0198-8859(94)90083-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7836064-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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