Polymorphism in the regulatory regions of the HLA-DPB1 gene.

doi:10.1016/s0198-8859(99)00084-1

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Article

Polymorphism in the regulatory regions of the HLA-DPB1 gene.

Human immunology - 1 Oct 1999

Varney M D, Gavrilidis A, Tait B D

Abstract excerpt

Nucleotide sequencing of approximately 400 basepairs upstream from exon 1 of the DPB1 gene and sequence specific oligonucleotide hybridisation identified eight nucleotide positions to be polymorphic which were in linkage disequilibrium (LD) with DPA1 and DPB1 alleles. Substitutions at two sites (-230 and -224) formed three genotypes (DP-PRO1-3). DP-PRO 1 was the most common genotype and was in LD with DPA1*0103,...

Topics

Binding Sites
Genes, MHC Class II
Genotype
HLA-DP Antigens
HLA-DP alpha-Chains
HLA-DP beta-Chains
Linkage Disequilibrium
Nuclear Proteins
Nucleic Acid Hybridization
Polymerase Chain Reaction
Polymorphism, Genetic
Promoter Regions, Genetic
Protein Binding
Sequence Analysis, DNA

Source

Open in PubMed

Identifiers

PMID: 10566595
DOI: 10.1016/s0198-8859(99)00084-1

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