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Article

Effect of genetic architecture on the power of human linkage studies to resolve the contribution of quantitative trait loci.

Heredity - 1 Feb 1994

Eaves L J

Abstract excerpt

The effect of genetic architecture (linkage relationships, dominance and two forms of non-allelic interaction) on the power of marker studies to detect, locate and analyse the contributions of specific quantitative trait loci (QTLs) to continuous human traits is considered for randomly mating populations in linkage equilibrium under a two-locus model. The expected regression of the within-sibling-pair mean-square...

Topics

Alleles
Chromosome Mapping
Genetic Linkage
Genetic Variation
Humans
Models, Genetic
Nuclear Family
Regression Analysis

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 8150657
DOI: 10.1038/hdy.1994.25

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8150657-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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