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Article

Epistasis in quantitative trait locus linkage analysis: interaction or main effect?

Behavior genetics - 1 Mar 2004

Purcell Shaun, Sham Pak C

Abstract excerpt

This paper explores a two-locus variance components model of quantitative trait locus (QTL) linkage for sib-pairs that incorporates epistasis. For a range of epistatic models the expected variance components and noncentrality parameter per sib-pair can be calculated, to indicate the power to detect epistasis. In QTL linkage analysis, additive and epistatic effects are in fact partially confounded; as a result,...

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Identifiers

PMID: 14755179
DOI: 10.1023/B:BEGE.0000013728.96408.f9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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