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Article

Linkage disequilibrium analysis of biallelic DNA markers, human quantitative trait loci, and threshold-defined case and control subjects.

American journal of human genetics - 1 Nov 2000

Schork N J, Nath S K, Fallin D, Chakravarti A

Abstract excerpt

Linkage disequilibrium (LD) mapping has been applied to many simple, monogenic, overtly Mendelian human traits, with great success. However, extensions and applications of LD mapping approaches to more complex human quantitative traits have not been straightforward. In this article, we consider the analysis of biallelic DNA marker loci and human quantitative trait loci in settings that involve sampling...

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PMID: 11032785
DOI: 10.1086/321201
PMCID: PMC1288563

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