Article
Contribution of an additive locus to genetic variance when inheritance is multi-factorial with implications on interpretation of GWAS.
TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik - 1 Jun 2013
Gianola Daniel, Hospital Frederic, Verrier Etienne
Abstract excerpt
Although the effects of linkage disequilibrium (LD) on partition of genetic variance have received attention in quantitative genetics, there has been little discussion on how this phenomenon affects attribution of variance to a given locus. This paper reinforces the point that standard metrics used for assessing the contribution of a locus to variance can be misleading when there is linkage LD and that factors...
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