Linkage analysis: principles and methods for the analysis of human quantitative traits.

doi:10.1375/1369052042335223

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Article

Linkage analysis: principles and methods for the analysis of human quantitative traits.

Twin research : the official journal of the International Society for Twin Studies - 1 Oct 2004

Ferreira Manuel A R

Abstract excerpt

Currently, mapping genes for complex human traits relies on two complementary approaches, linkage and association analyses. Both suffer from several methodological and theoretical limitations, which can considerably increase the type-1 error rate and reduce the power to map human quantitative trait loci (QTL). This review focuses on linkage methods for QTL mapping. It summarizes the most common linkage statistics...

Topics

Genetic Linkage
Genotype
Humans
Models, Genetic
Models, Statistical
Phenotype
Quantitative Trait Loci
Quantitative Trait, Heritable

Source

Open in PubMed

Identifiers

PMID: 15527667
DOI: 10.1375/1369052042335223

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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