Mutations in human CD4 impair the functional interaction with different human and mouse class II isotypes and alleles.

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Article

Mutations in human CD4 impair the functional interaction with different human and mouse class II isotypes and alleles.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 1996

Fleury S, Huang B, Zerbib A, Croteau G, Long E O, Sekaly R P

Abstract excerpt

The structure-function of the CD4-class II MHC interaction was investigated. Two functional assays were used to assess the responses of the 3DT52.5.8 murine T cell hybridoma expressing human CD4 (h-CD4) or murine CD4 (m-CD4). First, we determined the responses of the CD4+ and CD4-effector cells t...

Topics

Alleles
Animals
CD4 Antigens
Enterotoxins
Histocompatibility Antigens Class II
Humans
Mice
Mutation
Species Specificity
Staphylococcus aureus
Structure-Activity Relationship
Superantigens

Source

Open in PubMed

Identifiers

PMID: 8596036

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8596036-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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