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Article

Mutations in human CD4 impair the functional interaction with different human and mouse class II isotypes and alleles.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 1996

Fleury S, Huang B, Zerbib A, Croteau G, Long E O, Sekaly R P

Abstract excerpt

The structure-function of the CD4-class II MHC interaction was investigated. Two functional assays were used to assess the responses of the 3DT52.5.8 murine T cell hybridoma expressing human CD4 (h-CD4) or murine CD4 (m-CD4). First, we determined the responses of the CD4+ and CD4-effector cells toward DAP-3 cells co-expressing the cognate alloantigen H-2Dd together with several human (DRw52b, DR4-Dw4, DR2A, and...

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Identifiers

PMID: 8596036

Genes

DAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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