Article
Structure-function studies of T-cell receptor-superantigen interactions.
Immunological reviews - 1 Jun 1998
Li H, Llera A, Mariuzza R A
Abstract excerpt
Superantigens (SAGs) are a class of disease-causing and immunostimulatory proteins of bacterial or viral origin that activate T cells by binding to the V beta domain of the T-cell antigen receptor (TCR). The three-dimensional structure of the complex between a TCR beta chain (mouse V beta 8.2-J beta 2.1-C beta 1) and the SAG staphylococcal enterotoxin C3 (SEC3) has been recently determined. The...
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