The regulatory complex of HLA class I promoters exhibits locus-specific conservation with limited allelic variation.

Abstract excerpt

The extensive genetic polymorphism of the classical MHC class I molecules provides an important distinguishing feature of the host's immune system. They influence the selection and function of effector cells against tumor and virally infected cells. In these cells, class I molecules are often sel...

Topics

• Alleles
• Base Sequence
• Binding Sites
• DNA Primers
• Genes, MHC Class I
• Histocompatibility Antigens Class I
• Humans
• Molecular Sequence Data
• NF-kappa B
• Oligonucleotide Probes
• Promoter Regions, Genetic
• Sequence Alignment