A common mutation in the hominoid class I A-locus IFN-responsive element results in the loss of enhancer activity.

doi:10.1093/intimm/7.5.853

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Article

A common mutation in the hominoid class I A-locus IFN-responsive element results in the loss of enhancer activity.

International immunology - 1 May 1995

Vallejo A N, Allen K S, Pease L R

Abstract excerpt

Despite the observed coordinate expression of HLA-A and -B antigens in somatic tissues, there is growing evidence that the A and B class I genes are differentially regulated at the transcriptional level. Previous studies indicate that this may be related to locus-specific structural differences i...

Topics

Animals
Base Sequence
DNA-Binding Proteins
Enhancer Elements, Genetic
Genes, MHC Class I
HLA-A Antigens
Haplorhini
HeLa Cells
Humans
Interferon Regulatory Factor-1
Leukemia, Erythroblastic, Acute
Luciferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Molecular Sequence Data

Mutation

Phosphoproteins

Plasmids

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 7547711
DOI: 10.1093/intimm/7.5.853

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7547711-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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