Article
Cigarette smoking is strongly associated with mutation of the K-ras gene in patients with primary adenocarcinoma of the lung.
Cancer - 15 Sept 2001
Ahrendt S A, Decker P A, Alawi E A, Zhu Yr Y R, Sanchez-Cespedes M, Yang S C, Haasler G B, Kajdacsy-Balla A, Demeure M J, Sidransky D
Abstract excerpt
BACKGROUND: The majority of lung carcinoma cases occur in current or former smokers. K-ras gene mutations are common in lung adenocarcinoma and have been associated with cigarette smoking, asbestos exposure, and female gender. METHODS: In the current study, the authors examined the contribution of cigarette smoking to K-ras gene mutations in patients with primary lung adenocarcinoma. Smoking histories were...
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