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Article

Relationship between K-ras oncogene activation and smoking in adenocarcinoma of the human lung.

Journal of the National Cancer Institute - 17 Jul 1991

Slebos R J, Hruban R H, Dalesio O, Mooi W J, Offerhaus G J, Rodenhuis S

Abstract excerpt

To investigate a possible relationship between the exposure to tobacco smoke and the presence of ras point mutations, we examined lung adenocarcinoma samples from 27 smokers and from 27 nonsmokers. Activating point mutations in K-ras (also known as KRAS2) and N-ras (also known as NRAS) were deter...

Topics

Adenocarcinoma
Adult
Aged
Aged, 80 and over
Analysis of Variance
Codon
DNA, Neoplasm
Female
Gene Expression Regulation, Neoplastic
Genes, ras
Humans
Lung Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Mutation

Polymerase Chain Reaction

Smoking

Source

Identifiers

PMID: 2072410
DOI: 10.1093/jnci/83.14.1024

Genes

NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2072410-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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