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Article

Sequence of C. elegans lag-2 reveals a cell-signalling domain shared with Delta and Serrate of Drosophila.

Nature - 10 Mar 1994

Tax F E, Yeargers J J, Thomas J H

Abstract excerpt

The lin-12 and glp-1 genes of Caenorhabditis elegans encode members of the Notch family of transmembrane proteins. Genetic studies indicate that the lin-12 and glp-1 proteins act as receptors in specific developmental cell interactions and that their functions are partially redundant. lin-12 glp-1 double mutants display certain embryonic defects not found in either single mutant. The phenotype of this double...

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Identifiers

PMID: 8139658
DOI: 10.1038/368150a0

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EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Sequence of C. elegans lag-2 reveals a cell-signalling domain shared with Delta and Serrate of Drosophila.PMID 8139658Read ↗

Two homologous regulatory genes, lin-12 and glp-1, have overlapping functions.Semantic proximity Read ↗

APX-1 can substitute for its homolog LAG-2 to direct cell interactions throughout Caenorhabditis elegans development.Semantic proximity Read ↗

Evolution of discrete Notch-like receptors from a distant gene duplication in Caenorhabditis.Semantic proximity Read ↗

spr-2, a suppressor of the egg-laying defect caused by loss of sel-12 presenilin in Caenorhabditis elegans, is a member of the SET protein subfamily.Semantic proximity Read ↗

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene.Semantic proximity Read ↗

lag-1, a gene required for lin-12 and glp-1 signaling in Caenorhabditis elegans, is homologous to human CBF1 and Drosophila Su(H).Semantic proximity Read ↗

The lateral signal for LIN-12/Notch in C. elegans vulval development comprises redundant secreted and transmembrane DSL proteins.Semantic proximity Read ↗

SEL-5, a serine/threonine kinase that facilitates lin-12 activity in Caenorhabditis elegans.Semantic proximity Read ↗

Enhancers of glp-1, a gene required for cell-signaling in Caenorhabditis elegans, define a set of genes required for germline development.Semantic proximity Read ↗

Conservation of glp-1 regulation and function in nematodes.Semantic proximity Read ↗

HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling.Semantic proximity Read ↗

Isolation and characterization of Drosophila presenilin homologSemantic proximity Read ↗

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