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Article

lag-1, a gene required for lin-12 and glp-1 signaling in Caenorhabditis elegans, is homologous to human CBF1 and Drosophila Su(H).

Development (Cambridge, England) - 1 May 1996

Christensen S, Kodoyianni V, Bosenberg M, Friedman L, Kimble J

Abstract excerpt

The homologous receptors LIN-12 and GLP-1 mediate diverse cell-signaling events during development of the nematode Caenorhabditis elegans. These two receptors appear to be functionally interchangeable and have sequence similarity to Drosophila Notch. Here we focus on a molecular analysis of the lag-1 gene (lin-12 -and glp-1), which plays a central role in LIN-12 and GLP-1-mediated signal transduction. We find...

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Identifiers

PMID: 8625826
DOI: 10.1242/dev.122.5.1373

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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lag-1, a gene required for lin-12 and glp-1 signaling in Caenorhabditis elegans, is homologous to human CBF1 and Drosophila Su(H).PMID 8625826Read ↗

Two homologous regulatory genes, lin-12 and glp-1, have overlapping functions.Semantic proximity Read ↗

GLP-1 Notch - LAG-1 CSL control of the germline stem cell fate is mediated by transcriptional targets <i>lst-1</i> and <i>sygl-1</i>Semantic proximity Read ↗

Enhancers of glp-1, a gene required for cell-signaling in Caenorhabditis elegans, define a set of genes required for germline development.Semantic proximity Read ↗

Conservation of glp-1 regulation and function in nematodes.Semantic proximity Read ↗

HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling.Semantic proximity Read ↗

The CSL transcription factor LAG-1 directly represses hlh-6 expression in C. elegans.Semantic proximity Read ↗

DIV-1/PolA2 Promotes GLP-1/Notch-Mediated Cellular Events in <i>Caenorhabditis elegans</i>Semantic proximity Read ↗

Evolution of discrete Notch-like receptors from a distant gene duplication in Caenorhabditis.Semantic proximity Read ↗

Sequence of C. elegans lag-2 reveals a cell-signalling domain shared with Delta and Serrate of Drosophila.Semantic proximity Read ↗

UBR-5, a Conserved HECT-Type E3 Ubiquitin Ligase, Negatively Regulates Notch-Type Signaling in Caenorhabditis elegans.Semantic proximity Read ↗

The Caenorhabditis elegans sel-1 gene, a negative regulator of lin-12 and glp-1, encodes a predicted extracellular protein.Semantic proximity Read ↗

APX-1 can substitute for its homolog LAG-2 to direct cell interactions throughout Caenorhabditis elegans development.Semantic proximity Read ↗

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