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Article

Conservation of glp-1 regulation and function in nematodes.

Genetics - 1 Feb 2001

Rudel D, Kimble J

Abstract excerpt

The Caenorhabditis elegans (Ce) glp-1 gene encodes a Notch-like receptor. We have cloned glp-1 from C. briggsae (Cb) and C. remanei (Cr), two Caenorhabditis species that have diverged from C. elegans by roughly 20-40 million years. By sequence analysis, we find that the Cb-GLP-1 and Cr-GLP-1 proteins have retained the same motif architecture as Ce-GLP-1, including number of domains. In addition, two regions...

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Identifiers

PMID: 11156985
DOI: 10.1093/genetics/157.2.639
PMCID: PMC1461503

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