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Isolation and characterization of Drosophila presenilin homolog

1 Feb 1997

Abstract excerpt

Presenilin-1 (PS1) and presenilin-2 (PS2) are associated with a majority of early onset familial Alzheimer's disease (FAD). Sequence analysis of PS1/2 has revealed integral transmembrane proteins which are highly homologous to the protein coded by sel-12, a Caenorhabditis elegans gene involved in the lin-12/Notch signaling pathway. The normal function of PS1/2, as well as the pathogenesis caused by mutations of...

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PMID: 9106743
DOI: 10.1097/00001756-199702100-00017

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Isolation and characterization of Drosophila presenilin homologPMID 9106743Read ↗

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