APX-1 can substitute for its homolog LAG-2 to direct cell interactions throughout Caenorhabditis elegans development.

doi:10.1073/pnas.92.21.9839

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Article

APX-1 can substitute for its homolog LAG-2 to direct cell interactions throughout Caenorhabditis elegans development.

Proceedings of the National Academy of Sciences of the United States of America - 10 Oct 1995

Gao D, Kimble J

Abstract excerpt

The homologous LAG-2 and APX-1 membrane proteins are putative signaling ligands in the GLP-1/LIN-12 signal-transduction pathway in Caenorhabditis elegans. Normally, LAG-2 and APX-1 mediate distinct cell interactions. Here, we demonstrate that APX-1, which normally interacts with GLP-1 in the early embryo, can substitute for LAG-2 throughout development. When expressed under control of the lag-2 promoter, an apx-1...

Topics

Amino Acid Sequence
Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Cell Communication
Gonads
Helminth Proteins
Membrane Glycoproteins
Membrane Proteins
Models, Biological

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Receptors, Notch

Recombinant Fusion Proteins

Sequence Homology, Amino Acid

Signal Transduction

Sodium Channels

Source

Open in PubMed Open full text

Identifiers

PMID: 7568229
DOI: 10.1073/pnas.92.21.9839
PMCID: PMC40898

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7568229-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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