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Genetic Identification of Adenovirus Type 5 Genes That Influence Viral Spread

26 Jan 2006

Abstract excerpt

The mechanisms that control cell-to-cell spread of human adenoviruses (Ad) are not well understood. Two early viral proteins, E1B-19K and E3-ADP, appear to have opposing effects since viral mutants that are individually deficient in E1B-19K produce large plaques (G. Chinnadurai, Cell 33:759-766, 1983), while mutants deficient in E3-ADP produce small plaques (A. E. Tollefson et al., J. Virol. 70:2296-2306, 1996)...

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Identifiers

PMID: 16439556
DOI: 10.1128/jvi.80.4.2000-2012.2006

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