Article
Two subtypes of HLA-B51 differing by substitution at position 171 of the alpha 2 helix.
Immunogenetics - 1 Jan 1992
Kawaguchi G, Hildebrand W H, Hiraiwa M, Karaki S, Nagao T, Akiyama N, Uchida H, Kashiwase K, Akaza T, Williams R C
Abstract excerpt
Newly defined antigens of the B5, B35 cross-reacting group have been found in Japanese and North American Indians. Nucleotide sequencing of the alleles encoding the Japanese B5.35 antigen and the variant B5 antigen from the Piman Indians show them to be identical. This new allele, B*5102, differs from B*5101 by a single nucleotide substitution that changes residue 171 from histidine to tyrosine. Residue 171,...
Topics
- Amino Acid Sequence
- Base Sequence
- Biological Evolution
- Cells, Cultured
- DNA
- HLA-B Antigens
- Histidine
- Humans
- Indians, North American
- Japan
- Molecular Sequence Data