Article
Antibodies of different specificities are self-binding: implication for antibody diversity.
Molecular immunology - 1 Jul 1991
Kaveri S V, Halpern R, Kang C Y, Köhler H
Abstract excerpt
Antibodies of the S107/T15 germline family possess variable region structures which allow them to form specific complexes. We extended the investigation of the immunochemical properties of self-binding antibodies (autobodies) to mutant antibodies: U4, which binds DNA, and U10, which has no identi...
Topics
- Amino Acid Sequence
- Animals
- Antibody Diversity
- Antibody Specificity
- Autoantibodies
- Binding, Competitive
- DNA
- Immunoenzyme Techniques
- Immunoglobulin Heavy Chains
- Immunoglobulin Variable Region
- Mice
- Molecular Sequence Data
- Mutation
- Radioimmunoassay
- Tumor Cells, Cultured