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Article

Role of neurotrophins in mouse neuronal development.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jul 1994

Klein R

Abstract excerpt

During vertebrate development, naturally occurring neuronal cell death is regulated by target-derived peptide factors, called neurotrophins. A recent series of papers describe the phenotypes of germline-targeted mutant mice deficient in neurotrophins and their receptors. Histological analysis of...

Topics

Animals
Ganglia, Spinal
Mice
Mice, Mutant Strains
Motor Neurons
Nerve Growth Factors
Nervous System
Neurons, Afferent
Phenotype
Proprioception
Receptors, Nerve Growth Factor
Signal Transduction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Starvation

Source

Identifiers

PMID: 8050673
DOI: 10.1096/fasebj.8.10.8050673

Genes

BDNF
NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8050673-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Role of neurotrophins in mouse neuronal development.PMID 8050673Read ↗

Severe peripheral sensory neuron loss and modest motor neuron reduction in mice with combined deficiency of brain-derived neurotrophic factor, neurotrophin 3 and neurotrophin 4/5.Semantic proximity Read ↗

Dorsal root ganglion neurons require functional neurotrophin receptors for survival during development.Semantic proximity Read ↗

Role of neurotrophins and trk receptors in the development and maintenance of sensory neurons: an overview.Semantic proximity Read ↗

Expressing TrkC from the TrkA locus causes a subset of dorsal root ganglia neurons to switch fate.Semantic proximity Read ↗

Neurotrophins, nociceptors, and pain.Semantic proximity Read ↗

Differential dependency of cutaneous mechanoreceptors on neurotrophins, trk receptors, and P75 LNGFR.Semantic proximity Read ↗

Mice lacking brain-derived neurotrophic factor exhibit visceral sensory neuron losses distinct from mice lacking NT4 and display a severe developmental deficit in control of breathing.Semantic proximity Read ↗

Genetic evidence for cell death mediated by nerve growth factor and the neurotrophin receptor p75 in the developing mouse retina and spinal cord.Semantic proximity Read ↗

Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene.Semantic proximity Read ↗

Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements.Semantic proximity Read ↗

Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development.Semantic proximity Read ↗

Neurotrophins. Keeping track of changing neurotrophic theory.Semantic proximity Read ↗

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