Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of neurotrophins in mouse neuronal development.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jul 1994

Klein R

Abstract excerpt

During vertebrate development, naturally occurring neuronal cell death is regulated by target-derived peptide factors, called neurotrophins. A recent series of papers describe the phenotypes of germline-targeted mutant mice deficient in neurotrophins and their receptors. Histological analysis of these mice for the first time has provided knowledge about the specific neuron populations that are dependent on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to NGF gene
Share to Mice
Share to Mice, Mutant Strains

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Motor Neurons

Share to Nerve Growth Factors

Share to Nervous System

Share to Phenotype

Share to Signal Transduction

Source

Identifiers

PMID: 8050673
DOI: 10.1096/fasebj.8.10.8050673

Genes

BDNF
NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of neurotrophins in mouse neuronal development.PMID 8050673Read ↗

Severe peripheral sensory neuron loss and modest motor neuron reduction in mice with combined deficiency of brain-derived neurotrophic factor, neurotrophin 3 and neurotrophin 4/5.Semantic proximity Read ↗

Dorsal root ganglion neurons require functional neurotrophin receptors for survival during development.Semantic proximity Read ↗

Role of neurotrophins and trk receptors in the development and maintenance of sensory neurons: an overview.Semantic proximity Read ↗

Expressing TrkC from the TrkA locus causes a subset of dorsal root ganglia neurons to switch fate.Semantic proximity Read ↗

Neurotrophins, nociceptors, and pain.Semantic proximity Read ↗

Differential dependency of cutaneous mechanoreceptors on neurotrophins, trk receptors, and P75 LNGFR.Semantic proximity Read ↗

Mice lacking brain-derived neurotrophic factor exhibit visceral sensory neuron losses distinct from mice lacking NT4 and display a severe developmental deficit in control of breathing.Semantic proximity Read ↗

Genetic evidence for cell death mediated by nerve growth factor and the neurotrophin receptor p75 in the developing mouse retina and spinal cord.Semantic proximity Read ↗

Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene.Semantic proximity Read ↗

Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements.Semantic proximity Read ↗

Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development.Semantic proximity Read ↗

Neurotrophins. Keeping track of changing neurotrophic theory.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.